Bone marrow transplant: children
The data set describes pediatric patients with several hematologic diseases, who were subject to the unmanipulated allogeneic unrelated donor hematopoietic stem cell transplantation.
Characteristics
Subject Area
Associated Tasks
Attribute Type
# Instances
# Attributes
Info
The data set describes pediatric patients with several hematologic diseases: malignant disorders (i.a. acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, myelodysplastic syndrome) and nonmalignant cases (i.a. severe aplastic anemia, Fanconi anemia, with X-linked adrenoleukodystrophy). All patients were subject to the unmanipulated allogeneic unrelated donor hematopoietic stem cell transplantation.
The motivation of the study was to identify the most important factors influencing the success or failure of the transplantation procedure. In particular, the aim was to verify the hypothesis that increased dosage of CD34+ cells / kg extends overall survival time without simultaneous occurrence of undesirable events affecting patients' quality of life (Kawłak et al., 2010).
The data set has been used in our work concerning survival rules (Wróbel et al., 2017) and user-guided rule induction (Sikora et al., 2019). The authors of the research on stem cell transplantation (Kawłak et al., 2010) who inspired our study also contributed to the set.
Introductory Paper
By M. Sikora, Lukasz Wróbel, Adam Gudyś. 2018
Provided by
University of California, Irvine
Creators
- Marek Sikora
- Łukasz Wróbel
- Adam Gudyś
DOI
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Features
| Attribute Name | Role | Type | Demographic | Description | Units | Missing Values |
|---|---|---|---|---|---|---|
| Recipientgender | Feature | Binary | Gender | Male - 1, Female - 0 | no | |
| Stemcellsource | Feature | Binary | Source of hematopoietic stem cells (Peripheral blood - 1, Bone marrow - 0) | no | ||
| Donorage | Feature | Integer | Age | Age of the donor at the time of hematopoietic stem cells apheresis | no | |
| Donorage35 | Feature | Binary | Age | Donor age <35 - 0, Donor age >=35 - 1 | no | |
| IIIV | Feature | Binary | Development of acute graft versus host disease stage II or III or IV (Yes - 1, No - 0) | no | ||
| Gendermatch | Feature | Binary | Gender | Compatibility of the donor and recipient according to their gender (Female to Male - 1, Other - 0) | no | |
| DonorABO | Feature | Categorical | ABO blood group of the donor of hematopoietic stem cells (0 - 0, 1, A, B=-1, AB=2) | no | ||
| RecipientABO | Feature | Categorical | ABO blood group of the recipient of hematopoietic stem cells (0 - 0, 1, A, B=-1, AB=2) | yes | ||
| RecipientRh | Feature | Binary | Presence of the Rh factor on recipient s red blood cells ('+' - 1, '-' - 0) | yes | ||
| ABOmatch | Feature | Binary | Compatibility of the donor and the recipient of hematopoietic stem cells according to ABO blood group (matched - 1, mismatched - 1) | yes | ||
| CMVstatus | Feature | Categorical | Serological compatibility of the donor and the recipient of hematopoietic stem cells according to cytomegalovirus | yes | ||
| DonorCMV | Feature | Binary | resence of cytomegalovirus infection in the donor of hematopoietic stem cells prior to transplantation (present, absent) | yes | ||
| RecipientCMV | Feature | Binary | Presence of cytomegalovirus infection in the donor of hematopoietic stem cells prior to transplantation (presence - 1, absence - 0) | yes | ||
| Disease | Feature | Categorical | Type of disease (ALL,AML,chronic,nonmalignant,lymphoma) | no | ||
| Riskgroup | Feature | Binary | High risk - 1, Low risk - 0 | no | ||
| Txpostrelapse | Feature | Binary | The second bone marrow transplantation after relapse (No - 0; Yes - 1) | no | ||
| Diseasegroup | Feature | Binary | Type of disease (malignant - 1, nonmalignant - 0) | no | ||
| HLAmatch | Feature | Categorical | Compatibility of antigens of the main histocompatibility complex of the donor and the recipient of hematopoietic stem cells according to ALL international BFM SCT 2008 criteria (10/10 - 0, 9/10 - 1, 8/10 - 2, 7/10 - 3 (allele/antigens)) | no | ||
| HLAmismatch | Feature | Binary | HLA matched - 0, HL mismatched - 1 | no | ||
| Antigen | Feature | Categorical | In how many antigens there is difference beetwen the donor nad the recipient (-1 - no differences, 0 - one difference,1 (2) - two (three) differences) | yes | ||
| Allele | Feature | Categorical | In how many allele there is difference beetwen the donor nad the recipient {-1 no differences,0 - one difference, 1 (2) (3) - two, (tree, four) differences) | yes | ||
| HLAgrI | Feature | Categorical | The difference type between the donor and the recipient (HLA matched - 0,the difference is in only one antigen - 1, the difference is only in one allele - 2, the difference is only in DRB1 cell - 3, two differences (two allele or two antigens) - 4, two differences (two allele or two antigens) - 5) | no | ||
| Recipientage | Feature | Integer | Age | Age of the recipient of hematopoietic stem cells at the time of transplantation | no | |
| Recipientage10 | Feature | Binary | Age | Recipient age <10 - 0, Recipient age>=10 - 1 | no | |
| Recipientageint | Feature | Categorical | Age | Recipient age in (0,5] - 0, (5, 10] - 1, (10, 20] - 2 | no | |
| Relapse | Feature | Binary | Reoccurrence of the disease (No - 0, Yes - 1) | no | ||
| aGvHDIIIIV | Feature | Binary | Development of acute graft versus host disease stage III or IV (Yes - 0, No - 1) | no | ||
| extcGvHD | Feature | Binary | Development of extensive chronic graft versus host disease (Yes - 0, No - 1) | yes | ||
| CD34kgx10d6 | Feature | Integer | CD34+ cell dose per kg of recipient body weight | 10^6/kg | no | |
| CD3dCD34 | Feature | Integer | CD3+ cell to CD34+ cell ratio | yes | ||
| CD3dkgx10d8 | Feature | Integer | CD3+ cell dose per kg of recipient body weight | 10^8/kg | yes | |
| Rbodymass | Feature | Integer | Body mass of the recipient of hematopoietic stem cells at the time of transplantation | yes | ||
| ANCrecovery | Feature | Integer | Time to neutrophils recovery defined as neutrophils count >0.5 x 10^9/L | no | ||
| PLTrecovery | Feature | Integer | Time to platelet recovery defined as platelet count >50000/mm3 | no | ||
| time_to_aGvHD_III_IV | Feature | Integer | Time to development of acute graft versus host disease stage III or IV | no | ||
| survival_time | Feature | Integer | Time of observation (if alive) or time to event (if dead) in days | no | ||
| survival_status | Target | Integer | Survival status (0 - alive, 1 - dead) | no |